Mda vs mdma10/29/2022 ![]() ![]() While MDA has several additional production steps involved that require fairly advanced chemistry, especially compared to something like psilocybin mushrooms or cannabis flowers, it does still have roots in traditional plant medicines - as do most pharmaceuticals available.īefore conducting his self-experiment with MDA in 1927, chemist Gordon Alles had previously tested MDA on canine subjects, indicating that the drug consistently appeared to be one-third to one-half as active as mescaline and amphetamine. But, safrole oil is used in chemical manufacturing and industrial applications, as well as in one step of the production process for MDMA or MDA. Due to its carcinogenic properties, safrole oil is no longer used as an industrial food additive in rootbeers or candy. Safrole oil is the naturally occurring organic compound that makes the sassafras tree sweet and fragrant, and its leaves have been used in tea to induce a mild euphoric state. A synthetic version of safrole called isosafrole can also be used. Of these plant sources, the roots of the sassafras tree are most abundant in an important MDA precursor compound called safrole. Sometimes these precursors are synthesized from manufactured chemicals, other times they are isolated from natural plant sources. #MDA VS MDMA SERIES#MDA synthesis begins with several chemical precursors, ingredients that are combined through a series of chemical reactions until the final molecular structure is achieved. While there are many pathways for creating MDA, it is worth noting that MDA is manufactured from compounds isolated from medicinal plants that have long been used to treat asthma, fatigue, and even emotional distress. Like most psychedelics, MDA has roots in plant medicines with long histories of traditional use, though it would be incorrect to say that MDA is a naturally occurring plant medicine. MDA Synthesis and Roots in Plant Medicine Structurally similar to ephedrine and amphetamine, MDA was originally explored as an anti-fatigue medicine, but its psychoactive properties didn’t start gaining interest until chemist Gordon Alles first consumed MDA with the hope of identifying a new asthma medication. MDA was first synthesized in 1910 by two German chemists who were studying the stimulating effects of medicinal plants like sassafras, nutmeg, and calamus. And, before the Controlled Substances Act in 1970, MDA was used by therapists who had collectively produced a significant body of work indicating therapeutic effects, while the government was conducting secret trials. Throughout its cultural history, MDA, and MDA-type substances, have consistently popped up on the recreational scene. While MDMA has been granted breakthrough therapy status by the FDA for the treatment of PTSD, MDA has not yet come back into mainstream research as a potential treatment option. MDA and MDMA are both currently Schedule 1 drugs. While there are many similarities in their mechanisms, such as serotonin and dopamine release and binding to 5HT2A receptors, there are reports of differences between the substances. MDMA is even metabolized to MDA in the body after ingestion. So much so that MDA is frequently found, but often unnoticed, in samples of illicit MDMA. MDMA and MDA are very similar in structure overall. The additional “M” in MDMA’s name translates to the addition of a methyl group to the amphetamine backbone of the drug. #MDA VS MDMA FULL#What’s the Difference Between MDA and MDMA?įirst, let’s start with their full names: MDA is 3,4‐methylenedioxyamphetamine (MDA), while MDMA is 3,4‐methylenedioxymethamphetamine. Currently, only MDMA is being seriously considered for psychedelic therapy, although this may one day change. Though both can elicit powerful psychedelic experiences, they encountered prohibition at different times with similar impacts on the field of psychedelic therapy. While MDMA may be more popularly known today, MDA was frequently called the “Mellow Drug of America,” and the original “ hug-drug ”.Īside from sharing a familiar origin story, both drugs are psychedelic amphetamines that have been used in therapeutic settings and recreational environments. Benjamin Malcolm, PharmD, MPH, BCPPīefore the name “Ecstasy” was ever associated with MDMA and the underground dance scene, another psychedelic amphetamine was making its way through U.S. ![]()
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